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KMID : 1039220190290020195
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Journal of Korean Society of Occupational and Environmental Hygiene
2019 Volume.29 No. 2 p.195 ~ p.207
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The Study on Possibility of Use of Lead in Plasma as a Chronic Toxicity Biomarker
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Lee Sung-Bae
Lim Cheol-Hong
Kim Nam-Soo
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Abstract
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Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years,
Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary δ-aminolevulinic acid (δ-ALA) were measured for correlation analysis with plasma lead.
Results: The geometric mean concentration of lead in plasma was 0.23 ㎍/L for the retired lead workers and 0.10 ㎍/L for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased.
Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.
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KEYWORD
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General population, ICP/Mass, lead , plasma, retired lead worker
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